Nickel-Catalyzed Tandem Ueno-Stork Cyclization: Stereoselective 1,2-Dicarbofunctionalization of Cyclic Alkenes

J Org Chem. 2022 Jul 1;87(13):8796-8801. doi: 10.1021/acs.joc.2c00770. Epub 2022 Jun 22.

Abstract

A nickel-catalyzed tandem Ueno-Stork cyclization is developed to enable stereoselective 1,2-dicarbofunctionalization of cyclic alkenes and efficiently build various bicyclic products. This new protocol does not involve any toxic or difficult-to-remove tin reagent and is scalable and amenable to build all-carbon quaternary centers.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, N.I.H., Extramural

MeSH terms

  • Alkenes
  • Catalysis
  • Cyclization
  • Cycloparaffins*
  • Nickel*

Substances

  • Alkenes
  • Cycloparaffins
  • Nickel