Myocardial Infarction in a 29-Year-Old Woman Leads to Diagnosis and Treatment of a Rare Disease

Carma Karam; Nicolas Mansencal; Etienne Puymirat; Etienne Charpentier; Aurélien Palmyre; Thierry Chinet; Mostafa El Hajjam

doi:10.1016/j.chest.2022.01.066

Myocardial Infarction in a 29-Year-Old Woman Leads to Diagnosis and Treatment of a Rare Disease

Chest. 2022 Jul;162(1):e49-e52. doi: 10.1016/j.chest.2022.01.066.

Authors

Carma Karam¹, Nicolas Mansencal², Etienne Puymirat³, Etienne Charpentier⁴, Aurélien Palmyre⁵, Thierry Chinet⁶, Mostafa El Hajjam⁷

Affiliations

¹ Cardiology Department, Ambroise Paré Hospital, Assistance Publique des Hôpitaux de Paris, Boulogne, University of Versailles-Saint Quentin en Yvelines, Paris, France; Competence Centre for Hereditary Hemorrhagic Telangiectasia Disease, Ambroise Paré Hospital, Assistance Publique des Hôpitaux de Paris, Boulogne, University of Versailles-Saint Quentin en Yvelines, Paris, France. Electronic address: carma.karam@aphp.fr.
² Cardiology Department, Ambroise Paré Hospital, Assistance Publique des Hôpitaux de Paris, Boulogne, University of Versailles-Saint Quentin en Yvelines, Paris, France; INSERM U-1018, Centre de Recherche en Epidémiologie et Santé des Populations, Clinical Epidemiology, Université Saint Quentin en Yvelines, Villejuif, France.
³ Department of Cardiology, Georges Pompidou European Hospital, Assistance Publique des Hôpitaux de Paris, Paris, France.
⁴ Department of Radiology, Georges Pompidou European Hospital, Assistance Publique des Hôpitaux de Paris, Paris, France.
⁵ Competence Centre for Hereditary Hemorrhagic Telangiectasia Disease, Ambroise Paré Hospital, Assistance Publique des Hôpitaux de Paris, Boulogne, University of Versailles-Saint Quentin en Yvelines, Paris, France; Department of Genetics, Ambroise Paré Hospital, Assistance Publique des Hôpitaux de Paris, Boulogne, France.
⁶ Competence Centre for Hereditary Hemorrhagic Telangiectasia Disease, Ambroise Paré Hospital, Assistance Publique des Hôpitaux de Paris, Boulogne, University of Versailles-Saint Quentin en Yvelines, Paris, France; Pulmonary Department, Ambroise Paré Hospital, Assistance Publique des Hôpitaux de Paris, Boulogne, University of Versailles-Saint Quentin en Yvelines, Paris, France.
⁷ Competence Centre for Hereditary Hemorrhagic Telangiectasia Disease, Ambroise Paré Hospital, Assistance Publique des Hôpitaux de Paris, Boulogne, University of Versailles-Saint Quentin en Yvelines, Paris, France; Department of Radiology, Ambroise Paré Hospital, Assistance Publique des Hôpitaux de Paris, Boulogne, University of Versailles-Saint Quentin en Yvelines, Paris, France.

PMID: 35809950
DOI: 10.1016/j.chest.2022.01.066

Abstract

A 29-year-old woman without history of cardiac disease or risk factors sought treatment for sudden onset of chest pain radiating down the back, jaw, and arms, complicated by discomfort in the orthostatic position and severe headache. She had a history of epistaxis since childhood as well as familial history of epistaxis via her mother. BMI was 22 kg/m², and electrocardiography showed ST segment depression in V1V2 precordial leads and T-wave inversion in inferior leads. Troponin was elevated at 3,700 ng/L (normal, < 34 ng/L), with a peak of 11,115 ng/L.

Publication types

Case Reports

MeSH terms

Adult
Arrhythmias, Cardiac
Chest Pain
Child
Electrocardiography
Epistaxis
Female
Humans
Myocardial Infarction* / diagnosis
Rare Diseases*