First reported case of Lachnoanaerobaculum gingivalis bacteremia in an acute myeloid leukemia patient with oral mucositis during high dose chemotherapy

Naoto Okada; Akikazu Murakami; Masami Sato; Shingen Nakamura; Shiro Fujii; Kimiko Sogabe; Mamiko Takahashi; Asami Okada; Akane Abe; Hideki Fujii; Masahiro Abe; Momoyo Azuma; Keisuke Ishizawa

doi:10.1016/j.anaerobe.2022.102610

First reported case of Lachnoanaerobaculum gingivalis bacteremia in an acute myeloid leukemia patient with oral mucositis during high dose chemotherapy

Anaerobe. 2022 Aug:76:102610. doi: 10.1016/j.anaerobe.2022.102610. Epub 2022 Jul 8.

Authors

Naoto Okada¹, Akikazu Murakami², Masami Sato³, Shingen Nakamura⁴, Shiro Fujii⁵, Kimiko Sogabe⁵, Mamiko Takahashi⁵, Asami Okada⁶, Akane Abe³, Hideki Fujii⁷, Masahiro Abe⁵, Momoyo Azuma³, Keisuke Ishizawa⁸

Affiliations

¹ Department of Pharmacy, Tokushima University Hospital, Tokushima, Japan; Department of Infection Control and Prevention, Tokushima University Hospital, Tokushima, Japan. Electronic address: naoto-o@tokushima-u.ac.jp.
² Department of Oral Microbiology, Graduate School of Biomedical Sciences, Tokushima University Graduate School, Tokushima, Japan.
³ Department of Infection Control and Prevention, Tokushima University Hospital, Tokushima, Japan.
⁴ Department of Community Medicine and Medical Science, Tokushima University Graduate School of Biomedical Sciences, Tokushima, Japan.
⁵ Department of Hematology, Endocrinology and Metabolism, Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima, Japan.
⁶ Department of Pediatrics, Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima, Japan.
⁷ Department of Biology, Keio University School of Medicine, Yokohama, Japan.
⁸ Department of Pharmacy, Tokushima University Hospital, Tokushima, Japan; Department of Clinical Pharmacology and Therapeutics, Tokushima University Graduate School of Biomedical Sciences, Tokushima, Japan; Clinical Research Center for Developmental Therapeutics, Tokushima University Hospital, Tokushima, Japan.

PMID: 35811059
DOI: 10.1016/j.anaerobe.2022.102610

Abstract

Case description: Lachnoanaerobaculum gingivalis is an obligate anaerobe identified in a human dental plaque in 2019. Here, we report the first case of L. gingivalis bacteremia in a patient with oral mucositis during chemotherapy. L. gingivalis was confirmed by 16S rRNA gene analysis but not by MALDI-TOF-MS.

Conclusion: During chemotherapy in patients with oral mucositis, we should consider the possibility of L. gingivalis bacteremia.

Keywords: Acute myeloid leukemia; Bacteremia; Lachnoanaerobaculum gingivalis; Oral mucositis.

Publication types

Case Reports

MeSH terms

Bacteremia* / diagnosis
Bacteremia* / drug therapy
Clostridiales / genetics
Humans
Leukemia, Myeloid, Acute* / complications
Leukemia, Myeloid, Acute* / drug therapy
RNA, Ribosomal, 16S / genetics
Stomatitis* / diagnosis

Substances

RNA, Ribosomal, 16S