Ion-ing out the genetic variants of Kir2.1

Elife. 2022 Jul 11:11:e80718. doi: 10.7554/eLife.80718.

Abstract

Deep mutational scanning provides new insights into how mutations alter the expression and activity of the potassium ion channel Kir2.1, which is associated with many diseases.

Keywords: deep mutational scanning; folding; gating; genetics; genomics; high-throughput; ion channel; molecular biophysics; mouse; structural biology; variant effect prediction.

Publication types

  • Editorial

MeSH terms

  • Ion Channel Gating / genetics
  • Mutation
  • Potassium Channels, Inwardly Rectifying* / genetics
  • Potassium Channels, Inwardly Rectifying* / metabolism

Substances

  • Potassium Channels, Inwardly Rectifying