During June 2022, Spain was one of the countries most affected worldwide by a multicountry monkeypox outbreak with chains of transmission without identified links to disease-endemic countries. We provide epidemiologic features of cases reported in Spain and the coordinated measures taken to respond to this outbreak.
Keywords: MSM; Spain; bioterrorism and preparedness; control measures; epidemiologic features; men who have had sex with men; monkeypox; monkeypox viruses; multicountry; outbreak; response; viruses; zoonoses.