Effectiveness of Naturally Acquired and Vaccine-Induced Immune Responses to SARS-CoV-2 Mu Variant

Emerg Infect Dis. 2022 Aug;28(8):1708-1712. doi: 10.3201/eid2808.220584. Epub 2022 Jul 13.

Abstract

SARS-CoV-2 Mu variant emerged in Colombia in 2021 and spread globally. In 49 serum samples from vaccinees and COVID-19 survivors in Colombia, neutralization was significantly lower (p<0.0001) for Mu than a parental strain and variants of concern. Only the Omicron variant of concern demonstrated higher immune evasion.

Keywords: COVID-19; Colombia; SARS-CoV-2; acquired immunity; coronavirus disease; immune evasion; neutralization; severe acute respiratory syndrome coronavirus; vaccine efficacy; virus variants; viruses.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • COVID-19*
  • Humans
  • Immunity
  • SARS-CoV-2
  • Spike Glycoprotein, Coronavirus
  • Viral Vaccines*

Substances

  • Spike Glycoprotein, Coronavirus
  • Viral Vaccines
  • spike protein, SARS-CoV-2

Supplementary concepts

  • SARS-CoV-2 variants