The interplay of cytokine signaling and non-coding RNAs in head and neck squamous cell carcinoma pathobiology

Mol Biol Rep. 2022 Nov;49(11):10825-10847. doi: 10.1007/s11033-022-07770-x. Epub 2022 Jul 24.

Abstract

Head and neck squamous cell carcinoma (HNSCC) is a leading cause of cancer-related death worldwide. Despite aggressive treatment approaches, the recurrence of HNSCC remains a challenge. Cytokines play an essential role in HNSCC development and progression. They are not only involved in promoting cancer growth but may also be involved in an anti-tumor immune response. Non-coding RNAs (ncRNAs) have emerged as important transcriptional and post-transcriptional mediators of cytokine function in HNSCC. This review focuses on the complex regulatory network among regulatory ncRNAs and cytokines during HNSCC pathogenesis.

Keywords: Chemokines; Cytokines; HNSCC; circRNA; lncRNA; miRNA.

Publication types

  • Review

MeSH terms

  • Carcinoma, Squamous Cell* / genetics
  • Carcinoma, Squamous Cell* / pathology
  • Cytokines / genetics
  • Cytokines / metabolism
  • Gene Expression Regulation, Neoplastic / genetics
  • Head and Neck Neoplasms* / genetics
  • Humans
  • MicroRNAs* / genetics
  • MicroRNAs* / metabolism
  • RNA, Long Noncoding* / metabolism
  • RNA, Untranslated / genetics
  • Squamous Cell Carcinoma of Head and Neck / genetics

Substances

  • RNA, Long Noncoding
  • MicroRNAs
  • RNA, Untranslated
  • Cytokines