Vitamin D Levels in Black Americans and the Association With Left Ventricular Remodeling and Incident Heart Failure With Preserved Ejectin Fraction: The Jackson Heart Study

Abstract

Background: In observational studies, a lower serum vitamin D₃ concentration has been associated with an increased risk of cardiovascular disease. However, the associations between serum vitamin D₃ levels and left ventricular (LV) structure and heart failure with preserved ejection fraction (HFpEF) have not been well-characterized among Black Americans. The prevalence of vitamin D₃ deficiency is higher among Black Americans than in other race/ethnicity groups. We hypothesized that serum vitamin D₃ levels are associated with LV concentric remodeling and incident HFpEF in Black Americans.

Methods and results: Among 5306 Black Americans in the Jackson Heart Study cohort, we investigated the relationships between serum vitamin D₃ levels and LV structure and function, evaluated with echocardiography, and incident HF hospitalization, categorized as either HF with reduced EF (HFrEF; an EF of <50%) or HFpEF (an EF of ≥50%). After adjustment for possible confounding factors, lower vitamin D₃ levels were associated with greater relative wall thickness (β for 1 standard deviation [SD] increase -0.003, 95% confidence interval -0.005 to -0.000). Over a median follow-up period of 11 years (range 10.2-11.0 years), 340 participants developed incident HF (7.88 cases per 1000 person-years), including 146 (43%) HFrEF and 194 (57%) HFpEF cases. After adjustment, higher serum vitamin D₃ levels were associated with decreased hazard for HF overall (hazard ratio for 1 SD increase 0.88, 95% confidence interval 0.78-0.99) driven by a significant association with HFpEF (hazard ratio for 1 SD increase 0.84, 95% confidence interval 0.71-0.99).

Conclusions: In this community-based Black American cohort, lower serum vitamin D₃ levels were associated with LV concentric remodeling and an increased hazard for HF, mainly HFpEF. Further investigation is required to examine whether supplementation with vitamin D₃ can prevent LV concentric remodeling and incident HFpEF in Black Americans.

Keywords: Black Americans; Jackson Heart Study (JHS); Vitamin D; echocardiogram; heart failure.