Gluconeogenesis: Adding a new piece to the puzzle of malaria parasitism

Cell Metab. 2022 Aug 2;34(8):1083-1085. doi: 10.1016/j.cmet.2022.07.004.

Abstract

Disorders of carbohydrate metabolism, including hypoglycemia and lactic acidosis, are common features of malaria. In this issue of Cell Metabolism, Ramos et al. report that regulation of gluconeogenesis and glycemia by the host glucose-6-phosphatase catalytic subunit 1 (G6Pc1) is a key metabolic step that affects both Plasmodium replication and clinical outcome of disease.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, N.I.H., Extramural
  • Comment

MeSH terms

  • Acidosis, Lactic*
  • Blood Glucose / metabolism
  • Gluconeogenesis
  • Humans
  • Hypoglycemia* / metabolism
  • Malaria*

Substances

  • Blood Glucose