A Novel Pancreatic Cancer Mini-tumor Model to Study Desmoplasia and Myofibroblastic Cancer-Associated Fibroblast Differentiation

T J Harryvan; L J A C Hawinkels; mini-tumor workgroup; A Östman; P Ten Dijke; C Strell; M Hornsveld

doi:10.1016/j.gastha.2022.04.019

A Novel Pancreatic Cancer Mini-tumor Model to Study Desmoplasia and Myofibroblastic Cancer-Associated Fibroblast Differentiation

Gastro Hep Adv. 2022;1(4):678-681. doi: 10.1016/j.gastha.2022.04.019.

Authors

T J Harryvan¹, L J A C Hawinkels¹; mini-tumor workgroup; A Östman², P Ten Dijke³, C Strell⁴, M Hornsveld^{1

3}

Collaborators

mini-tumor workgroup:
A Inderson, J E van Hooft, P Micke, J S Johansen, T van Wezel, S Crobach, V M Baart, B S Quist, J E G Roet, M E Kop

Affiliations

¹ Department of Gastroenterology & Hepatology, Leiden University Medical Center, Leiden, The Netherlands.
² Department of Oncology-Pathology, Karolinska Institute, Stockholm, Sweden.
³ Department of Cell & Chemical Biology, Oncode Institute, Leiden University Medical Center, Leiden, The Netherlands.
⁴ Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden.

No abstract available

Keywords: CAF, cancer-associated fibroblasts; MT, minitumor; MyCAF, myofibroblastic CAF; PDAC, pancreatic ductal adenocarcinoma; PDGFR, platelet-derived growth factor receptor; PDO, pancreatic tumor-derived organoids; TGFβ, transforming growth factor β; αSMA, α-smooth muscle actin.

Publication types

Review