Immature Platelet Fraction as a Biomarker for Disease Severity in Pediatric Respiratory Coronavirus Disease 2019

Nicholas C J Lee; Yusuf Kemal Demir; Bilal Ashraf; Ibrahim Ibrahim; Taha Bat; Kathryn E Dickerson

doi:10.1016/j.jpeds.2022.07.035

Immature Platelet Fraction as a Biomarker for Disease Severity in Pediatric Respiratory Coronavirus Disease 2019

J Pediatr. 2022 Dec:251:187-189. doi: 10.1016/j.jpeds.2022.07.035. Epub 2022 Aug 6.

Authors

Nicholas C J Lee¹, Yusuf Kemal Demir², Bilal Ashraf¹, Ibrahim Ibrahim³, Taha Bat³, Kathryn E Dickerson⁴

Affiliations

¹ Departments of Internal Medicine and Pediatrics, University of Texas Southwestern, Dallas, TX.
² School of Data Science, University of North Carolina at Charlotte, Charlotte, NC.
³ Department of Internal Medicine, Division of Hematology and Oncology, University of Texas Southwestern Medical Center, Dallas, TX.
⁴ Department of Pediatrics, Division of Hematology/Oncology, University of Texas Southwestern Medical Center, Dallas, TX. Electronic address: Kathryn.Dickerson@UTSouthwestern.edu.

Abstract

In this retrospective single-institution cohort study of 113 hospitalized pediatric patients with respiratory coronavirus disease 2019, those admitted to the intensive care unit or requiring mechanical ventilation had significantly higher immature platelet fractions than those who did not require intensive care unit-level care or ventilation. Immature platelet fraction may be an accessible biomarker for disease severity in pediatric respiratory coronavirus disease 2019.

Keywords: COVID-19; SARS-CoV-2; biomarker; immature platelet; pediatric.

Publication types

Case Reports

MeSH terms

Biomarkers
COVID-19* / diagnosis
Child
Cohort Studies
Humans
Intensive Care Units
Respiration, Artificial
Retrospective Studies
SARS-CoV-2
Severity of Illness Index

Substances

Biomarkers