Multisystem T-cell Chronic Active Epstein-Barr Virus Infection: From the Eye to the Kidney

Guillaume Vial; Laure Barthod; Sophie Schneider; Patrick Mercié; Pierre Duffau; Agathe Vermorel; Emmanuel Ribeiro

doi:10.1093/ofid/ofac351

Multisystem T-cell Chronic Active Epstein-Barr Virus Infection: From the Eye to the Kidney

Open Forum Infect Dis. 2022 Aug 18;9(8):ofac351. doi: 10.1093/ofid/ofac351. eCollection 2022 Aug.

Authors

Guillaume Vial¹, Laure Barthod¹, Sophie Schneider¹, Patrick Mercié¹, Pierre Duffau¹, Agathe Vermorel², Emmanuel Ribeiro¹

Affiliations

¹ Department of Internal Medicine and Clinical Immunology, Saint Andre Hospital, University Hospital Centre of Bordeaux, Bordeaux, France.
² Department of Nephrology, Pellegrin Hospital, University Hospital Centre of Bordeaux, Bordeaux, France.

Abstract

Chronic active Epstein-Barr virus (CAEBV) infection is usually a fatal disease associated with clonal proliferation of EBV-infected T or NK cells. We present the case of a 33-year-old Peruvian patient who developed a multisystem CAEBV, notably responsible for exceptional ophthalmological and renal damage. We describe the clinicopathological features of EBV-induced lymphoproliferative disorder.

Keywords: Epstein-Barr virus; chronic active Epstein-Barr virus infection; lymphoproliferation; orbital myositis; tubulointerstitial nephritis.