Somatic symptom disorder in patients with post-COVID-19 neurological symptoms: a preliminary report from the somatic study (Somatic Symptom Disorder Triggered by COVID-19)

Alexandra Kachaner; Cédric Lemogne; Julie Dave; Brigitte Ranque; Thomas de Broucker; Elodie Meppiel

doi:10.1136/jnnp-2021-327899

Somatic symptom disorder in patients with post-COVID-19 neurological symptoms: a preliminary report from the somatic study (Somatic Symptom Disorder Triggered by COVID-19)

J Neurol Neurosurg Psychiatry. 2022 Aug 25:jnnp-2021-327899. doi: 10.1136/jnnp-2021-327899. Online ahead of print.

Authors

Alexandra Kachaner¹, Cédric Lemogne^{2

3}, Julie Dave⁴, Brigitte Ranque^{5

6}, Thomas de Broucker⁴, Elodie Meppiel⁴

Affiliations

¹ Internal Medicine, Université Paris Cité, Paris, France alexandra.kachaner@aphp.fr.
² Psychiatry, Université Paris Cité, INSERM U1266, Institut de Psychiatrie et Neuroscience de Paris, Paris, France.
³ , Service de Psychiatrie de l'adulte, AP-HP, Hôpital Hôtel-Dieu, Paris, France.
⁴ Neurology, Centre Hospitalier de Saint Denis, Saint Denis, France.
⁵ Internal Medicine, Internal Medicine Department, AP-HP, Hôpital Européen Georges Pompidou, Paris, France.
⁶ Université Paris Cité, Inserm UMR S970, Paris, France.

PMID: 36008115
DOI: 10.1136/jnnp-2021-327899

Abstract

Objectives: To assess the diagnosis of somatic symptom disorder (SSD) in patients with unexplained neurological symptoms occurring after SARS-CoV-2 infection, also referred to as long COVID.

Design: Single-centre observational study.

Participants: Adult patients experiencing unexplained long-lasting neurological symptoms after mild COVID. Of the 58 consecutive patients referred in our centre, 50 were included.

Intervention: Patients were contacted for a standardised psychometric evaluation by phone, followed by a self-survey.

Main outcome: Positive diagnosis of SSD according to the criteria of the Diagnostic and Statistical Manual of Mental Disorders-5 (DSM-5).

Results: Although the patients did not meet the DSM-5 criteria for a functional neurological symptom disorder specifically, SSD diagnosis based on DSM-5 criteria was positive in 32 (64%) patients. In the remaining 18 patients, SSD was considered possible given the high score on diagnostic scales. Physical examination were normal for all. Brain MRI showed unspecific minor white matter hyperintensities in 8/46 patients. Neuropsychological assessment showed exclusively mild impairment of attention in 14 out of 15 tested patients, in discrepancy with their major subjective complaint. Forty-five (90%) patients met criteria for Chronic Fatigue Syndrome. Seventeen (32%) patients were screened positive for mood-anxiety disorders, 19 (38%) had a history of prior SSD and 27 (54%) reported past trauma. Additional self-survey highlighted post-traumatic stress disorder in 12/43 (28%), high levels of alexithymia traits and perfectionism. Long-lasting symptoms had a major impact with a high rate of insomnia (29/43, 67%), psychiatric follow-up (28/50, 56%) and work or pay loss (25/50, 50%).

Conclusion: A majority of patients with unexplained long-lasting neurological symptoms after mild COVID met diagnostic criteria for SSD and may require specific management.

Trial registration number: NCT04889313.

Keywords: COVID-19; chronic fatigue syndrome; functional neurological disorder; somatisation disorder.

Associated data

ClinicalTrials.gov/NCT04889313