Potent and Selective PTDSS1 Inhibitors Induce Collateral Lethality in Cancers with PTDSS2 Deletion

Cancer Res. 2022 Nov 2;82(21):4031-4043. doi: 10.1158/0008-5472.CAN-22-1006.

Abstract

This study identifies a specific dependency on PTDSS1 for phosphatidylserine synthesis following PTDSS2 deletion and introduces novel PTDSS1 inhibitors as a therapeutic option to induce collateral lethality in cancer with PTDSS2 loss.

MeSH terms

  • Cell Line, Tumor
  • Humans
  • Neoplasms*