Bidirectional lysosome transport: a balancing act between ARL8 effectors

Nat Commun. 2022 Sep 7;13(1):5261. doi: 10.1038/s41467-022-32965-y.

Abstract

Most organelles move bidirectionally on microtubule tracks, yet how this opposing movement is regulated by kinesin and dynein remains unclear. Recent work found that ARL8, a known anterograde adaptor linking the lysosome to kinesin, also links lysosomes to the retrograde motor dynein, providing key insight into bidirectional organelle movement in cells.

MeSH terms

  • ADP-Ribosylation Factors* / metabolism
  • Biological Transport
  • Lysosomes* / metabolism

Substances

  • ADP-Ribosylation Factors