Ruthenium-Promoted On-DNA C-H Activation Reaction

Xuan Wang; Xiaojie Lu

doi:10.1007/978-1-0716-2545-3_10

Ruthenium-Promoted On-DNA C-H Activation Reaction

Methods Mol Biol. 2022:2541:63-66. doi: 10.1007/978-1-0716-2545-3_10.

Authors

Xuan Wang¹, Xiaojie Lu²

Affiliations

¹ State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China. wangxuan2@simm.ac.cn.
² State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.

PMID: 36083545
DOI: 10.1007/978-1-0716-2545-3_10

Abstract

DNA-compatible C-H activations expand the chemical space of DNA-encoded library. Here we describe the ruthenium-promoted C-H activation between DNA-conjugated acrylamides and aromatic acid.

Keywords: C-H activation reaction; DNA-encoded library (DEL); Ruthenium.

MeSH terms

Acrylamides
Catalysis
DNA
Gene Library
Ruthenium*

Substances

Acrylamides
Ruthenium
DNA