A Consideration of Fixed Dosing Versus Body Size-Based Dosing Strategies for Chimeric Antigen Receptor T-Cell Therapies

Clin Pharmacol Drug Dev. 2022 Oct;11(10):1130-1135. doi: 10.1002/cpdd.1171. Epub 2022 Sep 12.
No abstract available

Keywords: CAR-T cell therapies; cellular kinetics; exposure-response models; fixed and body-weight-based dosing.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Body Size
  • Humans
  • Immunotherapy, Adoptive
  • Receptors, Chimeric Antigen*
  • T-Lymphocytes

Substances

  • Receptors, Chimeric Antigen