Antiretroviral therapy achieved metabolic complete remission of hepatic AIDS related Epstein-Barr virus-associated smooth muscle tumor

Antivir Ther. 2022 Oct;27(5):13596535221126828. doi: 10.1177/13596535221126828.

Abstract

Epstein-Barr virus-associated smooth muscle tumor (EBV-SMT) is a rare mesenchymal tumor which occurs in immunocompromised patients. The immune status is an important factor in the treatment of EBV-SMTs, but the efficacy of antiretroviral therapy (ART) is not elucidated in acquired immune deficiency syndrome (AIDS) related EBV-SMTs. Here, we report the first successful case of a 29-year-old man with hepatic AIDS related EBV-SMT treated with ART solely. Positron emission tomography scan was useful for the evaluation of disease status. Recent advances in ART that enables to restore patient's immune status rapidly may change the treatment strategy in AIDS related EBV-SMT.

Keywords: Epstein-Barr virus; acquired immune deficiency syndrome; antiretroviral therapy; smooth muscle tumors.

Publication types

  • Case Reports

MeSH terms

  • Acquired Immunodeficiency Syndrome* / complications
  • Acquired Immunodeficiency Syndrome* / drug therapy
  • Adult
  • Epstein-Barr Virus Infections* / complications
  • Epstein-Barr Virus Infections* / drug therapy
  • HIV Infections* / complications
  • HIV Infections* / drug therapy
  • Herpesvirus 4, Human
  • Humans
  • Male
  • Smooth Muscle Tumor* / drug therapy
  • Smooth Muscle Tumor* / pathology