Successful treatment of rhino-cerebral mucormycosis with dual antifungal therapy and minimal surgical debridement

Lauren Bougioukas; Cindy D Noyes; Katherine Peterson; Lindsay M Smith; Andrew J Hale

doi:10.1016/j.idcr.2022.e01615

Successful treatment of rhino-cerebral mucormycosis with dual antifungal therapy and minimal surgical debridement

IDCases. 2022 Sep 6:30:e01615. doi: 10.1016/j.idcr.2022.e01615. eCollection 2022.

Authors

Lauren Bougioukas¹, Cindy D Noyes^{2

3}, Katherine Peterson², Lindsay M Smith^{2

3}, Andrew J Hale^{2

3}

Affiliations

¹ North Shore-Long Island Jewish Medical Center, Manhasset, NY, USA.
² University of Vermont Medical Center, Burlington, VT, USA.
³ Larner College of Medicine at the University of Vermont, Burlington, VT, USA.

Abstract

The authors report the case of a 42-year-old female with history of type I diabetes mellitus and recent episode of diabetic ketoacidosis who presented with symptoms of epistaxis, gastrointestinal upset, hyperglycemia, confusion, and a cough. She was found to have rhino-cerebral mucormycosis with associated multi-focal strokes and a left internal carotid artery pseudoaneurysm. Her infection was successfully treated with dual-antifungal therapy consisting of liposomal amphotericin B and isavuconazole, and required only minimal surgical debridement.

Keywords: Amphotericin B; Intracerebral; Invasive fungal infection; Isavuconazole; Liposomal amphotericin B; Mucormycosis; Rhino-cerebral mucormycosis.

Publication types

Case Reports