Unraveling phenotypic plasticity and evolution in small cell lung cancer

Cell Syst. 2022 Sep 21;13(9):687-689. doi: 10.1016/j.cels.2022.08.005.

Abstract

Malignant cell populations in a tumor often exist in distinct phenotypic states. Deciphering tumor heterogeneity requires determining how many such unique states exist and what the biological traits associated with each are. Archetype analysis of SCLC transcriptomes reveals key phenotypic states in SCLC tumors and their patterns of evolution.

Publication types

  • Research Support, N.I.H., Extramural
  • Comment

MeSH terms

  • Adaptation, Physiological
  • Humans
  • Lung Neoplasms* / genetics
  • Lung Neoplasms* / pathology
  • Phenotype
  • Small Cell Lung Carcinoma* / genetics
  • Small Cell Lung Carcinoma* / pathology