Bleeding, Hemorrhagic Shock, and the Global Blood Supply

Isabella Faria; Neil Thivalapill; Jennifer Makin; Juan Carlos Puyana; Nakul Raykar

doi:10.1016/j.ccc.2022.06.013

Bleeding, Hemorrhagic Shock, and the Global Blood Supply

Crit Care Clin. 2022 Oct;38(4):775-793. doi: 10.1016/j.ccc.2022.06.013.

Authors

Isabella Faria¹, Neil Thivalapill², Jennifer Makin³, Juan Carlos Puyana⁴, Nakul Raykar⁵

Affiliations

¹ Program in Global Surgery and Social Change, Harvard Medical School, 641 Hungtington Avenue, Boston, MA 02115, USA; Faculdade de Medicina da Universidade Federal de Minas Gerais, 190 Avenida Professor Alfredo Balena, Belo Horizonte, MG 31130450, Brazil.
² Institute for Public Health and Medicine, Northwestern University Feinberg School of Medicine, 420 East Superior Street, Chicago IL 60611, USA.
³ Department of Obstetrics, Gynecology and Reproductive Science, The University of Pittsburgh Medical Center Magee - Women's Hospital, 300 Halket Street, Pittsburgh, PA 15213, USA.
⁴ Critical Care Medicine, and Clinical Translational Science, Pittsburgh, PA 15213, USA; University of Pittsburgh, UPMC Presbyterian, F1263, 200 Lothrop Street, Pittsburgh, PA 15213, USA.
⁵ Program in Global Surgery and Social Change, Harvard Medical School, 641 Hungtington Avenue, Boston, MA 02115, USA; Division of Trauma & Emergency Surgery, Center for Surgery and Public Health, Brigham and Women's Hospital, 75 Francis Street, Boston, MA 02215, USA. Electronic address: nraykar@bwh.harvard.edu.

PMID: 36162910
DOI: 10.1016/j.ccc.2022.06.013

Abstract

Hemorrhage is responsible for at least 40% of deaths after trauma and 27% of maternal deaths worldwide. Patients with hemorrhagic shock require attentive critical care and transfusion of blood products. Access to a safe and affordable blood supply is critical to providing safe surgical care. Traumatic injury, obstetric hemorrhage, and upper gastrointestinal bleed are the main causes of severe bleeding requiring transfusion. This article discusses the presentation and management of these causes across the world and provides a brief overview of the current challenges in maintaining a global blood supply.

Keywords: Blood transfusion; Critical care; Global health; Hemorrhage; Hemorrhagic shock.

Publication types

Review

MeSH terms

Blood Transfusion
Female
Hemorrhage / etiology
Humans
Pregnancy
Shock, Hemorrhagic* / diagnosis
Shock, Hemorrhagic* / therapy

Grants and funding

UG3 HL151595/HL/NHLBI NIH HHS/United States