Mood disorders are mental health class that health professionals use to broadly describe all types of depression and bipolar disorders. Heritability of both bipolar and depressive disorder is in the range of 50%, which means that genes alone are not sufficient to explain all the cases of mood disorders, but they confer a substantial risk which is combined with environmental stressors to determine the final illness. In the recent years, a number of studies considered the idea to develop a strategic plan to employ the tools of genetics to advance the understanding, treatment, and outcomes for mood disorders.