Damaging Alleles Affecting Multiple CARD14 Domains Are Associated with Palmoplantar Pustulosis

Athanasios Niaouris; Ariana Hernández-Cordero; Salma Haddad; Niina Karoliina Hassi; Natashia Benzian-Olsson; Carmen Bugarin Diz; A David Burden; Hywel L Cooper; Christopher E M Griffiths; Richard Parslew; Andrew E Pink; Nick J Reynolds; Shyamal Wahie; Richard B Warren; Andrew Wright; Michael Simpson; Patrick Baum; Sudha Visvanathan; Jonathan N Barker; Catherine H Smith; Francesca Capon; APRICOT and PLUM study team

doi:10.1016/j.jid.2022.07.031

Damaging Alleles Affecting Multiple CARD14 Domains Are Associated with Palmoplantar Pustulosis

J Invest Dermatol. 2023 Mar;143(3):504-508.e5. doi: 10.1016/j.jid.2022.07.031. Epub 2022 Sep 27.

Authors

Athanasios Niaouris¹, Ariana Hernández-Cordero¹, Salma Haddad¹, Niina Karoliina Hassi¹, Natashia Benzian-Olsson¹, Carmen Bugarin Diz¹, A David Burden², Hywel L Cooper³, Christopher E M Griffiths⁴, Richard Parslew⁵, Andrew E Pink⁶, Nick J Reynolds⁷, Shyamal Wahie⁸, Richard B Warren⁹, Andrew Wright¹⁰, Michael Simpson¹, Patrick Baum¹¹, Sudha Visvanathan¹², Jonathan N Barker⁶, Catherine H Smith⁶, Francesca Capon¹³; APRICOT and PLUM study team

Collaborators

Affiliations

¹ Department of Medical & Molecular Genetics, School of Basic & Medical Biosciences, King's College London, London, United Kingdom.
² Institute of Infection Immunity and Inflammation, University of Glasgow, Glasgow, United Kingdom.
³ Portsmouth Dermatology Unit, Portsmouth Hospitals Trust, Portsmouth, United Kingdom.
⁴ Dermatology Centre, NIHR Manchester Biomedical Research Centre, University of Manchester, Manchester, United Kingdom.
⁵ Department of Dermatology, NHS Foundation Trust, Royal Liverpool Hospitals, Liverpool, United Kingdom.
⁶ St John's Institute of Dermatology, School of Basic & Medical Biosciences, King's College London, London, United Kingdom.
⁷ Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, United Kingdom; Department of Dermatology and NIHR Newcastle Biomedical Research Centre, Newcastle Hospitals NHS Foundation Trust, Newcastle upon Tyne, United Kingdom.
⁸ Department of Dermatology, University Hospital of North Durham, Durham, United Kingdom; Department of Dermatology, Darlington Memorial Hospital, Darlington, United Kingdom.
⁹ The Dermatology Centre, Salford Royal NHS Foundation Trust, University of Manchester, Manchester Academic Health Science Centre, Manchester, United Kingdom.
¹⁰ Department of Dermatology, St Lukes Hospital, Bradford, United Kingdom; Centre for Skin Science, University of Bradford, Bradford, United Kingdom.
¹¹ Boehringer Ingelheim International, Biberach, Germany.
¹² Boehringer Ingelheim Pharmaceuticals, Ridgefield, Connecticut, USA.
¹³ Department of Medical & Molecular Genetics, School of Basic & Medical Biosciences, King's College London, London, United Kingdom. Electronic address: francesca.capon@kcl.ac.uk.

PMID: 36174714
DOI: 10.1016/j.jid.2022.07.031

No abstract available

Publication types

Research Support, Non-U.S. Gov't
Letter

MeSH terms

Alleles
CARD Signaling Adaptor Proteins
Exanthema*
Guanylate Cyclase
Humans
Membrane Proteins
Psoriasis* / genetics

Substances

CARD14 protein, human
Guanylate Cyclase
Membrane Proteins
CARD Signaling Adaptor Proteins

Publication types

MeSH terms

Substances

Grants and funding