Hematological manifestations of antiphospholipid syndrome: Going beyond thrombosis

Blood Rev. 2023 Mar:58:101015. doi: 10.1016/j.blre.2022.101015. Epub 2022 Sep 16.

Abstract

Thrombotic complications are a hallmark of antiphospholipid syndrome (APS). These vascular - arterial, venous, and/or small vessel - complications are well described and known to hematologists and healthcare providers caring for patients with this disease. In this review, we shed light on other hematological manifestations of the disease, including bleeding, thrombocytopenia, autoimmune hemolytic anemia, and thrombotic microangiopathy syndromes. While these manifestations are not bona fide clinical criteria for the diagnosis of APS, they frequently interact and contribute to the complexity of clinical management of APS.

Keywords: Anemia; Antiphospholipid; Bleeding; Bone marrow diseases; Hemolysis; Thrombocytopenia.

Publication types

  • Review

MeSH terms

  • Anemia, Hemolytic, Autoimmune* / diagnosis
  • Anemia, Hemolytic, Autoimmune* / etiology
  • Anemia, Hemolytic, Autoimmune* / therapy
  • Antiphospholipid Syndrome* / complications
  • Antiphospholipid Syndrome* / diagnosis
  • Antiphospholipid Syndrome* / therapy
  • Cardiovascular Diseases*
  • Humans
  • Thrombocytopenia* / diagnosis
  • Thrombocytopenia* / etiology
  • Thrombosis* / diagnosis
  • Thrombosis* / etiology