Pseudogout growing from the temporomandibular joint into the middle cranial fossa

Oral Maxillofac Surg. 2024 Mar;28(1):441-445. doi: 10.1007/s10006-022-01117-3. Epub 2022 Oct 4.

Abstract

Calcium pyrophosphate dihydrate deposition disease (CPDD or pseudogout) is a degenerative joint disease. It is defined by the presence of calcium pyrophosphate dihydrate crystals. It usually manifests in the knee and wrist. Manifestation in the temporomandibular joint (TMJ) is only reported in case reports. We present a patient with CPDD mimicking a malignant tumor of the TMJ. A 53-year-old woman presented with progressive pain and a slow-growing swelling of the left TMJ. Imaging showed an extensive mass in the infratemporal fossa extending into the middle cranial fossa and compressing the temporal lobe. Assuming a potential malignancy, we excised the growth, which extended into the dura. We covered the resulting tissue defect within the primary surgery using a microsurgically anastomosed scapular flap and performed further reconstructive surgeries. Calcium pyrophosphate dihydrate crystals were found in the histopathologic examination of the excised tissue, resulting in the diagnosis of CPDD. That is a benign diagnosis, but we treated it like a malignancy. This leads us to the question, was there overtreatment? Tumoral CPDD in the TMJ can be a difficult diagnosis to obtain. The treatment remains controversial, but complete excision of the mass was performed in most reported cases.

Keywords: Calcium pyrophosphate dihydrate deposition disease; Pseudogout; TMJ; Tophaceous; Tumor of the skull base; Tumoral.

Publication types

  • Case Reports

MeSH terms

  • Calcium Pyrophosphate
  • Chondrocalcinosis* / diagnostic imaging
  • Chondrocalcinosis* / surgery
  • Cranial Fossa, Middle / diagnostic imaging
  • Cranial Fossa, Middle / pathology
  • Cranial Fossa, Middle / surgery
  • Female
  • Humans
  • Middle Aged
  • Neoplasms* / pathology
  • Temporomandibular Joint / diagnostic imaging
  • Temporomandibular Joint / surgery

Substances

  • Calcium Pyrophosphate