Fluorescein-guided surgery for intradural spinal tumors: A single-center experience

Salvatore Massimiliano Cardali; Giuseppe Ricciardo; Giada Garufi; Giovanni Raffa; Francesco Messineo; Gianluca Scalia; Alfredo Conti; Antonino Germanò

doi:10.1016/j.bas.2022.100908

Fluorescein-guided surgery for intradural spinal tumors: A single-center experience

Brain Spine. 2022 Jun 22:2:100908. doi: 10.1016/j.bas.2022.100908. eCollection 2022.

Authors

Salvatore Massimiliano Cardali¹, Giuseppe Ricciardo², Giada Garufi¹, Giovanni Raffa¹, Francesco Messineo², Gianluca Scalia³, Alfredo Conti^{4

5}, Antonino Germanò¹

Affiliations

¹ Division of Neurosurgery, BIOMORF Department, University of Messina, Messina, Italy.
² Neurosurgery Unit, Papardo Hospital, Messina, Italy.
³ Neurosurgery Unit, Highly Specialized Hospital and of National Importance "Garibaldi", Catania, Italy.
⁴ Department of Neurosurgery, IRCCS Istituto Delle Scienze Neurologiche Di Bologna, Via Altura 3, 40139, Bologna, Italy.
⁵ Department of Biomedical and Neuromotor Sciences (DIBINEM), University of Bologna, Bologna, Italy.

Abstract

•Gross total removal has a pivotal role in surgical treatment of intradural spinal tumors.•Sodium fluorescein prevents vascular injuries also preserving pial vessels in posterior myelotomy.•Fluorescence before the durotomy helps to distinguishing tumor from healthy tissue in intradural lesions.•Intraoperative fluorescence is safe and effective, also preserving functional anatomy in tumor removal.

Keywords: GTR, gross total removal; IONM, intraoperative neuromonitoring; MR, magnetic resonance; iUS, intraoperative ultrasound.