3-Silyl-3-Borylhex-4-Enoate: A Chiral Reagent for Asymmetric Crotylboration of Aldehydes

Org Lett. 2022 Oct 28;24(42):7822-7827. doi: 10.1021/acs.orglett.2c03195. Epub 2022 Oct 17.

Abstract

A nonracemic 3-silyl-3-borylhex-4-enoate reagent has been developed. Its asymmetric crotylboration of aldehydes provides Z-anti-homoallylic alcohols possessing a trisubstituted vinylsilane in high yields with excellent stereo- and enantioselectivity. Diverse decoration of vinylsilane and ester groups, as well as formation of functionalized THF rings, showcase the potential of the approach in the synthesis of polyketide natural products.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aldehydes*
  • Indicators and Reagents
  • Silanes*
  • Stereoisomerism

Substances

  • Aldehydes
  • vinylsilane
  • Indicators and Reagents
  • Silanes