Temporal scaling of human scalp-recorded potentials

Proc Natl Acad Sci U S A. 2022 Oct 25;119(43):e2214638119. doi: 10.1073/pnas.2214638119. Epub 2022 Oct 18.

Abstract

Much of human behavior is governed by common processes that unfold over varying timescales. Standard event-related potential analysis assumes fixed-duration responses relative to experimental events. However, recent single-unit recordings in animals have revealed neural activity scales to span different durations during behaviors demanding flexible timing. Here, we employed a general linear modeling approach using a combination of fixed-duration and variable-duration regressors to unmix fixed-time and scaled-time components in human magneto-/electroencephalography (M/EEG) data. We use this to reveal consistent temporal scaling of human scalp-recorded potentials across four independent electroencephalogram (EEG) datasets, including interval perception, production, prediction, and value-based decision making. Between-trial variation in the temporally scaled response predicts between-trial variation in subject reaction times, demonstrating the relevance of this temporally scaled signal for temporal variation in behavior. Our results provide a general approach for studying flexibly timed behavior in the human brain.

Keywords: EEG; regression; timing.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Brain Mapping
  • Electroencephalography* / methods
  • Evoked Potentials / physiology
  • Humans
  • Reaction Time / physiology
  • Scalp* / physiology