Dihydropyrimidine dehydrogenase (DPD) genotype and phenotype among Danish cancer patients: prevalence and correlation between DPYD-genotype variants and P-uracil concentrations

Niels Herluf Paulsen; Camilla Qvortrup; Fie Juhl Vojdeman; Peter Plomgaard; Stig Ejdrup Andersen; Anne Ramlov; Birgitte Bertelsen; Maria Rossing; Claus Gyrup Nielsen; Elke Hoffmann-Lücke; Eva Greibe; Hanne Spangsberg Holm; Heidi Hvid Nielsen; Ihab Bishara Yousef Lolas; Jonna Skov Madsen; Marianne Lerbaek Bergmann; Morten Mørk; Palle B Nielsen Fruekilde; Pernille Bøttger; Peter Clausager Petersen; Peter Henrik Nissen; Søren Feddersen; Troels K Bergmann; Per Pfeiffer; Per Damkier

doi:10.1080/0284186X.2022.2132117

Dihydropyrimidine dehydrogenase (DPD) genotype and phenotype among Danish cancer patients: prevalence and correlation between DPYD-genotype variants and P-uracil concentrations

Acta Oncol. 2022 Nov;61(11):1400-1405. doi: 10.1080/0284186X.2022.2132117. Epub 2022 Oct 18.

Authors

Niels Herluf Paulsen^{1

2}, Camilla Qvortrup³, Fie Juhl Vojdeman⁴, Peter Plomgaard^{5

6}, Stig Ejdrup Andersen⁷, Anne Ramlov⁸, Birgitte Bertelsen⁹, Maria Rossing^{6

10}, Claus Gyrup Nielsen¹¹, Elke Hoffmann-Lücke^{12

13}, Eva Greibe^{12

13}, Hanne Spangsberg Holm¹⁴, Heidi Hvid Nielsen¹⁵, Ihab Bishara Yousef Lolas¹⁶, Jonna Skov Madsen^{17

18}, Marianne Lerbaek Bergmann¹⁷, Morten Mørk^{11

16}, Palle B Nielsen Fruekilde¹⁹, Pernille Bøttger^{17

18}, Peter Clausager Petersen²⁰, Peter Henrik Nissen^{12

21}, Søren Feddersen^{19

22}, Troels K Bergmann^{1

23}, Per Pfeiffer^{14

22}, Per Damkier^{1

2

22}

Affiliations

¹ Department of Clinical Pharmacology, Odense University Hospital, Odense, Denmark.
² Clinical Pharmacology, Pharmacy and Environmental Medicine Department of Public Health, University of Southern Denmark, Odense, Denmark.
³ Department of Oncology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
⁴ Department of Clinical Biochemistry, Holbaek Hospital, Holbaek, Denmark.
⁵ Department of Clinical Biochemistry, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.
⁶ Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.
⁷ Clinical Pharmacology Unit, Zealand University Hospital, Roskilde, Denmark.
⁸ Department of Oncology, Aarhus University Hospital, Aarhus, Denmark.
⁹ Center for Genomic Medicine, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.
¹⁰ Center for Genomic Medicine, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
¹¹ Department of Clinical Biochemistry, Aalborg University Hospital, Aalborg, Denmark.
¹² Department of Clinical Biochemistry, Aarhus University Hospital, Aarhus N, Denmark.
¹³ Institute for Clinical Medicine, Aarhus University of Health, Aarhus, Denmark.
¹⁴ Department of Oncology, Odense University Hospital, Odense, Denmark.
¹⁵ Department of Clinical Biochemistry, Zealand University Hospital, Køge, Denmark.
¹⁶ Department of Molecular Diagnostics, Aalborg University Hospital, Aalborg, Denmark.
¹⁷ Department of Biochemistry and Immunology, Lillebaelt Hospital - University Hospital of Southern Denmark, Vejle, Denmark.
¹⁸ Department of Regional Health Research, University of Southern Denmark, Odense, Denmark.
¹⁹ Department of Clinical Biochemistry, Odense University Hospital, Odense, Denmark.
²⁰ Department of Oncology, Zealand University Hospital, Roskilde, Denmark.
²¹ Denmark and Institute for Clinical Medicine, Aarhus University, Aarhus, Denmark.
²² Department of Clinical Research, University of Southern Denmark, Odense, Denmark.
²³ Department of Regional Health Research, University of Southern Denmark, Esbjerg, Denmark.

PMID: 36256873
DOI: 10.1080/0284186X.2022.2132117

No abstract available

Publication types

Letter

MeSH terms

Denmark / epidemiology
Dihydrouracil Dehydrogenase (NADP)* / genetics
Fluorouracil
Genotype
Humans
Neoplasms* / epidemiology
Neoplasms* / genetics
Phenotype
Prevalence
Uracil

Substances

Dihydrouracil Dehydrogenase (NADP)
Uracil
Fluorouracil