Dalbavancin as chronic antibiotic suppression therapy for left ventricular assist device driveline infection due to methicillin-resistant Staphylococcus aureus: a case report

J Chemother. 2023 Sep;35(5):465-469. doi: 10.1080/1120009X.2022.2136426. Epub 2022 Oct 25.

Abstract

Left Ventricular Assist Devices (LVADs) represent an important therapeutic option in the management of advanced heart failure. We report a case of 74 years-old male with a Jarvik 2000® (Jarvik Heart, New York, USA) LVAD who presented with an infection of the LVAD driveline due to methicillin-resistant Staphylococcus aureus (MRSA) that was treated with dalbavancin as chronic antimicrobial suppression therapy without adverse events and maintaining a good quality of life for more than 37 weeks. Dalbavancin could represent a valid option for the treatment of LVAD infections because of its efficacy, pharmacokinetic/pharmacodynamic proprieties, safety and tolerability.

Keywords: Jarvik 2000; MRSA; chronic antimicrobial suppression therapy; dalbavancin; driveline infection; left ventricular assist devices.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Anti-Bacterial Agents / therapeutic use
  • Heart-Assist Devices* / adverse effects
  • Humans
  • Male
  • Methicillin-Resistant Staphylococcus aureus*
  • Prosthesis-Related Infections* / drug therapy
  • Quality of Life

Substances

  • dalbavancin
  • Anti-Bacterial Agents