Neuroprotective Role of MiRNA-9 in Neurological Diseases: A Mini Review

Abstract

MicroRNAs (miRNAs) are a class of non-coding small RNAs with about 22 nucleotides in eukaryotes. They regulate gene expression at the post-transcriptional level and play a key role in physiological and pathological processes. As one of the most abundant miRNAs in the human brain, miRNA-9 (miR-9) has attracted extensive attention due to its important role in the maintenance of normal function of the nervous system and the occurrence and development of nervous system diseases. Hence, we reviewed the neuroprotective effect of miR-9 in neurological diseases. MiR-9 may be a potential target of nervous system diseases.

Keywords: Alzheimer’s disease; MiRNA-9; neonatal hypoxic-ischemic encephalopathy; nervous system disease; neuroprotection; spinal cord injury; stroke; traumatic brain injury.