Cumulative risk assessment of five phthalates in European children and adolescents

Rosa Lange; Nina Vogel; Phillipp Schmidt; Antje Gerofke; Mirjam Luijten; Wieneke Bil; Tiina Santonen; Greet Schoeters; Liese Gilles; Amrit K Sakhi; Line S Haug; Tina K Jensen; Hanne Frederiksen; Holger M Koch; Tamás Szigeti; Máté Szabados; Janja Snoj Tratnik; Darja Mazej; Catherine Gabriel; Dimosthenis Sarigiannis; Vazha Dzhedzheia; Spyros Karakitsios; Loïc Rambaud; Margaux Riou; Gudrun Koppen; Adrian Covaci; Martin Zvonař; Pavel Piler; Jana Klánová; Lucia Fábelová; Denisa Richterová; Tina Kosjek; Agneta Runkel; Susana Pedraza-Díaz; Veerle Verheyen; Michiel Bastiaensen; Marta Esteban-López; Argelia Castaño; Marike Kolossa-Gehring

doi:10.1016/j.ijheh.2022.114052

Cumulative risk assessment of five phthalates in European children and adolescents

Int J Hyg Environ Health. 2022 Sep:246:114052. doi: 10.1016/j.ijheh.2022.114052. Epub 2022 Oct 30.

Authors

Rosa Lange¹, Nina Vogel², Phillipp Schmidt², Antje Gerofke², Mirjam Luijten³, Wieneke Bil³, Tiina Santonen⁴, Greet Schoeters⁵, Liese Gilles⁶, Amrit K Sakhi⁷, Line S Haug⁷, Tina K Jensen⁸, Hanne Frederiksen⁹, Holger M Koch¹⁰, Tamás Szigeti¹¹, Máté Szabados¹¹, Janja Snoj Tratnik¹², Darja Mazej¹², Catherine Gabriel¹³, Dimosthenis Sarigiannis¹⁴, Vazha Dzhedzheia¹³, Spyros Karakitsios¹³, Loïc Rambaud¹⁵, Margaux Riou¹⁵, Gudrun Koppen⁶, Adrian Covaci¹⁶, Martin Zvonař¹⁷, Pavel Piler¹⁷, Jana Klánová¹⁷, Lucia Fábelová¹⁸, Denisa Richterová¹⁸, Tina Kosjek¹², Agneta Runkel¹², Susana Pedraza-Díaz¹⁹, Veerle Verheyen⁶, Michiel Bastiaensen¹⁶, Marta Esteban-López¹⁹, Argelia Castaño¹⁹, Marike Kolossa-Gehring²

Affiliations

¹ German Environment Agency (UBA), Corrensplatz 1, 14195, Berlin, Germany. Electronic address: rosa.lange@uba.de.
² German Environment Agency (UBA), Corrensplatz 1, 14195, Berlin, Germany.
³ National Institute for Public Health and the Environment (RIVM), Antonie van Leeuwenhoeklaan 9, 3721, MA, Bilthoven, the Netherlands.
⁴ Finnish Institute of Occupational Health (FIOH), Helsinki, Finland.
⁵ VITO Health, Flemish Institute for Technological Research (VITO), Mol, Belgium; University of Antwerp, Department of Biomedical Sciences and Toxicological Centre, Antwerp, Belgium.
⁶ VITO Health, Flemish Institute for Technological Research (VITO), Mol, Belgium.
⁷ Department of Food Safety, Norwegian Institute of Public Health, Oslo, Norway.
⁸ Department of Clinical Pharmacology, Pharmacy and Environmental Medicine, University of Southern Denmark, Denmark.
⁹ Department of Growth and Reproduction and International Center for Research and Research Training in Endocrine Disruption of Male Reproduction and Child Health, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark.
¹⁰ Institute for Prevention and Occupational Medicine of the German Social Accident Insurance - Institute of the Ruhr University Bochum (IPA), Bochum, Germany.
¹¹ National Public Health Center, Albert Flórián út 2-6., 1097, Budapest, Hungary.
¹² Jožef Stefan Institute (JSI), Department of Environmental Sciences, Jamova 39, 1000, Ljubljana, Slovenia.
¹³ Environmental Engineering Laboratory, Department of Chemical Engineering, Aristotle University of Thessaloniki, 54124, Thessaloniki, Greece; HERACLES Research Center on the Exposome and Health, Center for Interdisciplinary Research and Innovation, Balkan Center, Bldg. B, 10th km Thessaloniki-Thermi Road, 57001, Greece.
¹⁴ Environmental Engineering Laboratory, Department of Chemical Engineering, Aristotle University of Thessaloniki, 54124, Thessaloniki, Greece; HERACLES Research Center on the Exposome and Health, Center for Interdisciplinary Research and Innovation, Balkan Center, Bldg. B, 10th km Thessaloniki-Thermi Road, 57001, Greece; Environmental Health Engineering, Institute of Advanced Study, Palazzo del Broletto - Piazza Della Vittoria 15, 27100, Pavia, Italy.
¹⁵ Department of Environmental and Occupational Health, Santé publique France, National Public Health Agency, Saint-Maurice, France.
¹⁶ Toxicological Center, University of Antwerp, Universiteitsplein 1, 2610, Wilrijk, Belgium.
¹⁷ RECETOX (Research Centre for Toxic Compounds in the Environment), Faculty of Science, Masaryk University, Kotlarska 2, Brno, Czech Republic.
¹⁸ Slovak Medical University in Bratislava, Faculty of Public Health, Department of Environmental Medicine, Limbova 12, 833 03, Bratislava, Slovakia.
¹⁹ National Centre for Environmental Health, Instituto de Salud Carlos III (ISCIII), Madrid, Spain.

PMID: 36323174
DOI: 10.1016/j.ijheh.2022.114052

No abstract available

Keywords: Cumulative risk assessment; HBM4EU; Human biomonitoring; Mixtures; Phthalates.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Adolescent
Child
Environmental Exposure / analysis
Environmental Monitoring
Environmental Pollutants*
Humans
Phthalic Acids*
Risk Assessment

Substances

phthalic acid
Phthalic Acids
Environmental Pollutants