Vade-MECOM: How to peel back the layers of hematopoiesis

Andrea Ditadi; Vijay G Sankaran

doi:10.1016/j.stem.2022.10.007

Vade-MECOM: How to peel back the layers of hematopoiesis

Cell Stem Cell. 2022 Nov 3;29(11):1512-1514. doi: 10.1016/j.stem.2022.10.007.

Authors

Andrea Ditadi¹, Vijay G Sankaran²

Affiliations

¹ San Raffaele Telethon Institute for Gene Therapy, IRCCS San Raffaele Scientific Institute, Milan, Italy. Electronic address: ditadi.andrea@hsr.it.
² Division of Hematology/Oncology, Boston Children's Hospital and Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA. Electronic address: sankaran@broadinstitute.org.

PMID: 36332568
DOI: 10.1016/j.stem.2022.10.007

Abstract

A recent study¹ demonstrates how hematopoietic stem cells (HSCs) contribute minimally to blood and immune cell production during development and only become active postnatally. The work also reveals how Mecom expression can be used to distinguish rare HSCs from the more abundant progenitors that arise to maintain embryonic hematopoiesis.

Publication types

Comment

MeSH terms

Cell Differentiation
Embryonic Development
Hematopoiesis*
Hematopoietic Stem Cells* / metabolism
Transcription Factors / metabolism

Substances

Transcription Factors