Prominent Intrapulmonary Shunt Vessels and Altered Lung Development in Infants With Sudden Unexplained Infant Death

Csaba Galambos; Douglas Bush; Steven H Abman; Michael Caplan

doi:10.1016/j.jpeds.2022.10.026

Prominent Intrapulmonary Shunt Vessels and Altered Lung Development in Infants With Sudden Unexplained Infant Death

J Pediatr. 2023 Apr:255:214-219.e1. doi: 10.1016/j.jpeds.2022.10.026. Epub 2022 Nov 3.

Authors

Csaba Galambos¹, Douglas Bush², Steven H Abman³, Michael Caplan⁴

Affiliations

¹ Department of Pathology and Laboratory Medicine, University of Colorado School of Medicine, Aurora, CO; Department of Pediatrics, University of Colorado School of Medicine, Aurora, CO. Electronic address: csaba.galambos@childrenscolorado.org.
² Department of Pediatrics, Icahn School of Medicine at Mount Sinai, New York, NY.
³ Department of Pediatrics, University of Colorado School of Medicine, Aurora, CO.
⁴ Lake Erie College of Osteopathic Medicine, Erie, PA.

PMID: 36336004
DOI: 10.1016/j.jpeds.2022.10.026

Abstract

The purpose of this study was to evaluate intrapulmonary arteriovenous shunts in patients with and without sudden unexplained infant death. We identified open intrapulmonary bronchopulmonary anastomoses as potential pathways for right-to-left shunt in a subset of infants with sudden unexplained infant death.

Keywords: SUID; alveolar growth abnormality; asphyxia score; intrapulmonary bronchopulmonary anastomoses; lung histology.

Publication types

Case Reports
Research Support, Non-U.S. Gov't

MeSH terms

Arteriovenous Malformations
Female
Heart Defects, Congenital
Humans
Infant
Infant Death
Lung* / diagnostic imaging
Male
Sudden Infant Death* / etiology