1 Donnelly Centre, University of Toronto, Toronto, ON, Canada; Department of Biochemistry, University of Toronto, Toronto, ON, Canada; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada; Mediterranean Institute for Life Sciences (MedILS), Split, Croatia; School of Medicine, University of Split, Croatia. Electronic address: igor.stagljar@utoronto.ca.