Liver Disease and Treatment Needs of Asymptomatic Persons Living With Hepatitis B in Senegal

Adrià Ramírez Mena; Mame Aissé Thioubou; Kalilou Diallo; Judicaël Tine; Ndeye Fatou Ngom; Louise Fortes; Kiné Ndiaye; Jean-Claude Karasi; Carole Seguin-Devaux; Henri Goedertz; Daouda Diouf; Moussa Seydi; Benjamin Amaye Sambou; Vic Arendt; Gilles Wandeler; Noël Magloire Manga; for SEN-B and CARES

doi:10.1093/ofid/ofac558

Liver Disease and Treatment Needs of Asymptomatic Persons Living With Hepatitis B in Senegal

Open Forum Infect Dis. 2022 Oct 28;9(11):ofac558. doi: 10.1093/ofid/ofac558. eCollection 2022 Nov.

Authors

Adrià Ramírez Mena^{1

2

3}, Mame Aissé Thioubou⁴, Kalilou Diallo⁵, Judicaël Tine¹, Ndeye Fatou Ngom⁶, Louise Fortes¹, Kiné Ndiaye⁶, Jean-Claude Karasi⁷, Carole Seguin-Devaux⁸, Henri Goedertz⁷, Daouda Diouf⁹, Moussa Seydi¹, Benjamin Amaye Sambou⁹, Vic Arendt⁷, Gilles Wandeler^{1

2

10}, Noël Magloire Manga⁵; for SEN-B and CARES

Affiliations

¹ Department of Infectious and Tropical Diseases, Fann University Hospital, Dakar, Senegal.
² Department of Infectious Diseases, Bern University Hospital, University of Bern, Bern, Switzerland.
³ Graduate School of Health Sciences, University of Bern, Bern, Switzerland.
⁴ Department of Gastroenterology, Hôpital Universitaire de la Paix, Ziguinchor, Senegal.
⁵ Department of Infectious Diseases, Hôpital Universitaire de la Paix, Ziguinchor, Senegal.
⁶ Centre de Traitement Ambulatoire, Fann University Hospital, Dakar, Senegal.
⁷ Department of Infectious Diseases, Centre Hospitalier du Luxembourg, Luxembourg, Luxembourg.
⁸ Department of Infection and Immunity, Luxembourg Health Institute, Luxembourg, Luxembourg.
⁹ ENDA (Environnement, Développement et Action) Santé, Dakar, Senegal.
¹⁰ Institute of Social and Preventive Medicine, University of Bern, Bern, Switzerland.

Abstract

The prevalence of active hepatitis B among asymptomatic persons remains unclear in Africa. Of 1206 newly diagnosed persons in Senegal, 12.3% had significant fibrosis and 31.3% had hepatitis B virus (HBV) DNA levels >2000 IU/mL. Overall, 128 (12.9%) were eligible for antiviral therapy. Generalized HBV screening allowed the identification of a large population requiring HBV care.

Keywords: Senegal; hepatitis B; liver fibrosis.