Dysfunctional subsets of CD39+ T cells, distinct from PD-1+, driven by leukemic extracellular vesicles in myeloid leukemias

Julian Swatler; Domenico Lo Tartaro; Rebecca Borella; Marta Brewinska-Olchowik; Annamaria Paolini; Anita Neroni; Laura Turos-Korgul; Milena Wiech; Ewa Kozlowska; Dominik Cysewski; Wioleta Grabowska-Pyrzewicz; Urszula Wojda; Grzegorz Basak; Rafael J Argüello; Andrea Cossarizza; Sara De Biasi; Katarzyna Piwocka

doi:10.3324/haematol.2022.281713

Dysfunctional subsets of CD39+ T cells, distinct from PD-1+, driven by leukemic extracellular vesicles in myeloid leukemias

Haematologica. 2023 Mar 1;108(3):909-916. doi: 10.3324/haematol.2022.281713.

Authors

Julian Swatler¹, Domenico Lo Tartaro², Rebecca Borella², Marta Brewinska-Olchowik³, Annamaria Paolini², Anita Neroni², Laura Turos-Korgul³, Milena Wiech³, Ewa Kozlowska⁴, Dominik Cysewski⁵, Wioleta Grabowska-Pyrzewicz⁶, Urszula Wojda⁶, Grzegorz Basak⁷, Rafael J Argüello⁸, Andrea Cossarizza⁹, Sara De Biasi¹⁰, Katarzyna Piwocka¹¹

Affiliations

¹ Laboratory of Cytometry, Nencki Institute of Experimental Biology, Warsaw, Poland; Department of Medical and Surgical Sciences for Children and Adults, University of Modena and Reggio Emilia, Modena.
² Department of Medical and Surgical Sciences for Children and Adults, University of Modena and Reggio Emilia, Modena.
³ Laboratory of Cytometry, Nencki Institute of Experimental Biology, Warsaw.
⁴ Department of Immunology, Faculty of Biology, University of Warsaw, Warsaw.
⁵ Laboratory of Mass Spectrometry, Institute of Biochemistry and Biophysics, Warsaw, Poland; Current address: Clinical Research Centre, Medical University of Bialystok, Bialystok.
⁶ Laboratory of Preclinical Testing of Higher Standard, Nencki Institute of Experimental Biology, Warsaw.
⁷ Department of Hematology, Transplantation and Internal Medicine, Medical University of Warsaw,Warsaw.
⁸ Aix Marseille University, CNRS, INSERM, CIML, Centre d'Immunologie de Marseille-Luminy, Marseille.
⁹ Department of Medical and Surgical Sciences for Children and Adults, University of Modena and Reggio Emilia, Modena, Italy; National Institute for Cardiovascular Research, Bologna.
¹⁰ Department of Medical and Surgical Sciences for Children and Adults, University of Modena and Reggio Emilia, Modena. debiasisara@yahoo.it.
¹¹ Laboratory of Cytometry, Nencki Institute of Experimental Biology, Warsaw. k.piwocka@nencki.edu.pl.

No abstract available

Publication types

Research Support, Non-U.S. Gov't
Letter

MeSH terms

Adenosine Triphosphate
Apyrase
Humans
Leukemia, Myeloid*
Programmed Cell Death 1 Receptor*
T-Lymphocytes

Substances

Programmed Cell Death 1 Receptor
Adenosine Triphosphate
Apyrase

Grants and funding

Funding: This work was supported by EMBO Scientific Exchange Grant (short-term fellowship) STF 8905 (to JS), Polish National Science Center grant 2018/29/N/NZ3/01754 (to JS) and Foundation for Polish Science grant TEAM TECH Core Facility Plus/2017-2/2 (POIR.04.04.00-00-23C2/17-00, co-financed by the European Union under the European Regional Development Fund) (to KP). SDB was the Marylou Ingram Scholar of the International Society for Advancement of Cytometry (ISAC) for the period 2016–2020. RJA is the Marylou Ingram Scholar of the International Society for Advancement of Cytometry (ISAC) for the period 2020–2023.