Spermatogonial Stem Cells and In Vitro Spermatogenesis: How Far Are We from a Human Testis on a Chip?

Christian K Ramsoomair; Charles G Alver; Ryan Flannigan; Ranjith Ramasamy; Ashutosh Agarwal

doi:10.1016/j.euf.2022.11.006

Spermatogonial Stem Cells and In Vitro Spermatogenesis: How Far Are We from a Human Testis on a Chip?

Eur Urol Focus. 2023 Jan;9(1):46-48. doi: 10.1016/j.euf.2022.11.006. Epub 2022 Nov 14.

Authors

Christian K Ramsoomair¹, Charles G Alver², Ryan Flannigan³, Ranjith Ramasamy¹, Ashutosh Agarwal⁴

Affiliations

¹ Desai Sethi Urology Institute, University of Miami Miller School of Medicine, Miami, FL, USA.
² Desai Sethi Urology Institute, University of Miami Miller School of Medicine, Miami, FL, USA; Department of Biomedical Engineering, University of Miami, Coral Gables, FL, USA.
³ Department of Urologic Sciences, The University of British Columbia, Vancouver, BC, Canada.
⁴ Desai Sethi Urology Institute, University of Miami Miller School of Medicine, Miami, FL, USA; Department of Biomedical Engineering, University of Miami, Coral Gables, FL, USA. Electronic address: a.agarwal2@miami.edu.

Abstract

An in vitro testis model will provide a superior platform for studying the testis microenvironment and molecular mechanisms that affect male fertility. The ultimate aim is to provide reproductive hope for children diagnosed with cancer who were sterilized by aggressive gonadotoxic therapies.

Publication types

Research Support, N.I.H., Extramural

MeSH terms

Child
Humans
Lab-On-A-Chip Devices
Male
Spermatogenesis
Spermatogonia*
Stem Cells
Testis*

Abstract

Publication types

MeSH terms

Grants and funding