Purpose: The goal of this study is to determine if certain aspects of endophthalmitis prophylaxis strategies are superior to others.
Design: This investigation is a systematic review and meta-analysis.
Methods: All studies specifying a type of prophylaxis strategy and resulting rates of endophthalmitis were included. Time course, method of administration, and antibiotic regimen, and confounding factors were collected and included for meta-regression.
Results: Time courses greater than 24 h did not significantly improve outcomes. Likewise, intraocular and/or intravenous antibiotic administration methods did not significantly outperform oral administration. No antibiotic regimens performed differently from vancomycin/ ≥ 3rd generation cephalosporin except for ciprofloxacin monotherapy which yielded significantly worse outcomes.
Conclusions: Future antibiotic strategies should strongly consider the risks of antibiotic treatment > 24 h and administration methods other than the oral antibiotic forms. In addition, providers should be wary of using ciprofloxacin monotherapy for endophthalmitis prophylaxis when treating open globe injuries.
Keywords: Endophthalmitis; Meta-analysis; Open globe; Post-traumatic; Prophylaxis; Systematic review.
© 2022. The Author(s).