Quick drop of platelet counts in children with chronic immune thrombocytopenia after COVID-19 mRNA vaccination: case reports

Giuseppe Lassandro; Francesco Carriero; Valentina Palladino; Giovanni Carlo Del Vecchio; Paola Giordano

doi:10.7774/cevr.2022.11.3.290

Quick drop of platelet counts in children with chronic immune thrombocytopenia after COVID-19 mRNA vaccination: case reports

Clin Exp Vaccine Res. 2022 Sep;11(3):290-293. doi: 10.7774/cevr.2022.11.3.290. Epub 2022 Sep 30.

Authors

Giuseppe Lassandro¹, Francesco Carriero¹, Valentina Palladino¹, Giovanni Carlo Del Vecchio¹, Paola Giordano¹

Affiliation

¹ Department Interdisciplinary of Medicine, Pediatric Unit "B. Trambusti", University of Bari "Aldo Moro", Bari, Italy.

Abstract

Immune thrombocytopenia (ITP) is an autoimmune disorder characterized by isolated thrombocytopenia. Many viruses and some vaccines have been identified as triggering the autoimmune process, including parvovirus, human immunodeficiency virus, Epstein-Barr virus, rubella, and measles. However, ITP in association with coronavirus disease 2019 (COVID-19) vaccination has not been reported so far. We describe the cases of two young girls affected by ITP presenting a quick reduction of platelet count after receiving Pfizer-BioNTech COVID-19 vaccine.

Keywords: COVID-19; Case report; Child; Immune thrombocytopenia.

Publication types

Case Reports