Microglia autophagy in ischemic stroke: A double-edged sword

Li Peng; Guangqiang Hu; Qianfang Yao; Jianming Wu; Ziyang He; Betty Yuen-Kwan Law; Guishan Hu; Xiaogang Zhou; Junrong Du; Anguo Wu; Lu Yu

doi:10.3389/fimmu.2022.1013311

Microglia autophagy in ischemic stroke: A double-edged sword

Front Immunol. 2022 Nov 16:13:1013311. doi: 10.3389/fimmu.2022.1013311. eCollection 2022.

Authors

Li Peng^{1

2

3}, Guangqiang Hu⁴, Qianfang Yao^{1

2}, Jianming Wu^{1

2}, Ziyang He^{1

2}, Betty Yuen-Kwan Law⁵, Guishan Hu^{1

2}, Xiaogang Zhou^{1

2}, Junrong Du⁶, Anguo Wu^{1

2}, Lu Yu^{1

2

3

7}

Affiliations

¹ Sichuan Key Medical Laboratory of New Drug Discovery and Druggability Evaluation, School of Pharmacy, Southwest Medical University, Luzhou, China.
² Luzhou Key Laboratory of Activity Screening and Druggability Evaluation for Chinese Materia Medica, School of Pharmacy, Southwest Medical University, Luzhou, China.
³ Department of Medicine Imaging, School of Clinical Medicine, Southwest Medical University, Luzhou, China.
⁴ Department of Anatomy, School of Basic Medical Sciences, Southwest Medical University, Luzhou, China.
⁵ State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Macao, Macao SAR, China.
⁶ Key Laboratory of Drug Targeting and Drug Delivery Systems of Ministry of Education, Department of Pharmacology, West China School of Pharmacy, Sichuan University, Chengdu, China.
⁷ Department of Chemistry, School of Basic Medical Sciences, Southwest Medical University, Luzhou, China.

Abstract

Ischemic stroke (IS) is one of the major types of cerebrovascular diseases causing neurological morbidity and mortality worldwide. In the pathophysiological process of IS, microglia play a beneficial role in tissue repair. However, it could also cause cellular damage, consequently leading to cell death. Inflammation is characterized by the activation of microglia, and increasing evidence showed that autophagy interacts with inflammation through regulating correlative mediators and signaling pathways. In this paper, we summarized the beneficial and harmful effects of microglia in IS. In addition, we discussed the interplay between microglia autophagy and ischemic inflammation, as along with its application in the treatment of IS. We believe this could help to provide the theoretical references for further study into IS and treatments in the future.

Keywords: autophagy; ischemic stroke; microglia; neuroinflammation; therapy.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Autophagy
Cell Death
Humans
Inflammation
Ischemic Stroke*
Microglia*