Biodegradation of Pine Processionary Caterpillar Silk Is Mediated by Elastase- and Subtilisin-like Proteases

Int J Mol Sci. 2022 Dec 3;23(23):15253. doi: 10.3390/ijms232315253.

Abstract

Pine processionary caterpillar nests are made from raw silk. Fibroin protein is the main component of silk which, in the case of pine processionary caterpillar, has some unusual properties such as a higher resistance to chemical hydrolysis. Isolation of microorganisms naturally present in silk nests led to identification of Bacillus licheniformis and Pseudomonas aeruginosa strains that in a defined minimal medium were able to carry out extensive silk biodegradation. A LasB elastase-like protein from P. aeruginosa was shown to be involved in silk biodegradation. A recombinant form of this protein expressed in Escherichia coli and purified by affinity chromatography was able to efficiently degrade silk in an in vitro assay. However, silk biodegradation by B. licheniformis strain was mediated by a SubC subtilisin-like protease. Homologous expression of a subtilisin Carlsberg encoding gene (subC) allowed faster degradation compared to the biodegradation kinetics of a wildtype B. licheniformis strain. This work led to the identification of new enzymes involved in biodegradation of silk materials, a finding which could lead to possible applications for controlling this pest and perhaps have importance from sanitary and biotechnological points of view.

Keywords: Bacillus; Pseudomonas; biodegradation; elastase; pine processionary; proteases; silk; subtilisin.

MeSH terms

  • Animals
  • Bacillus licheniformis* / genetics
  • Moths*
  • Pancreatic Elastase
  • Silk
  • Subtilisins / genetics

Substances

  • Silk
  • Pancreatic Elastase
  • Subtilisins

Grants and funding

Alba Diez-Galán (EDU/556/2019), Ana Ibañez (EDU/529/2017) and Carla Calvo-Peña (EDU/601/2020) were supported by a predoctoral contract from the Junta de Castilla y León and the European Social Fund.