Endosonography-Guided Tissue Acquisition for Diagnosis of Squamous Carcinoma of the Pancreas: A Report of Three Cases

José C Ardengh; Otavio Micelli-Neto; Rafael Kemp; José Sebastião Dos Santos

doi:10.7759/cureus.31344

Endosonography-Guided Tissue Acquisition for Diagnosis of Squamous Carcinoma of the Pancreas: A Report of Three Cases

Cureus. 2022 Nov 10;14(11):e31344. doi: 10.7759/cureus.31344. eCollection 2022 Nov.

Authors

José C Ardengh^{1

2}, Otavio Micelli-Neto³, Rafael Kemp¹, José Sebastião Dos Santos¹

Affiliations

¹ Surgery and Anatomy, Hospital das Clinicas, Faculty of Medicine, University of São Paulo, Ribeirão Preto, BRA.
² Diagnostic Imaging, Universidade Federal de São Paulo, São Paulo, BRA.
³ Digestive Endoscopy Service, Hospital Moriah, São Paulo, BRA.

Abstract

While approximately 85% of neoplasms are ductal pancreatic adenocarcinomas (DPA), adenosquamous pancreatic carcinoma (APC) is a rare subtype of pancreatic cancer that exhibits aggressive behavior and poor prognosis. The authors report three cases of primary APC diagnosed through endoscopic ultrasound-guided tissue acquisition (EUS-TA) using the new ProCore 20G needle, which had been developed to improve fine-needle aspiration results by providing more tissue for histopathology. Given its ability for microcore retrieval, pancreatic stroma examination, and excellent histopathology results, EUS-TA has exhibited exceptional diagnostic yield among patients with solid pancreatic lesions. All three APC cases presented herein had been accurately diagnosed using immunohistochemistry after microcore acquisition.

Keywords: adenosquamous carcinoma; carcinoma pancreas; endosonography; needle biopsy; tissue viability.

Publication types

Case Reports