T cell-independent abscopal responses to radiotherapy

Emma Guilbaud; Takahiro Yamazaki; Lorenzo Galluzzi

doi:10.1016/j.trecan.2022.12.005

T cell-independent abscopal responses to radiotherapy

Trends Cancer. 2023 Feb;9(2):93-95. doi: 10.1016/j.trecan.2022.12.005. Epub 2022 Dec 20.

Authors

Emma Guilbaud¹, Takahiro Yamazaki¹, Lorenzo Galluzzi²

Affiliations

¹ Department of Radiation Oncology, Weill Cornell Medical College, New York, NY, USA.
² Department of Radiation Oncology, Weill Cornell Medical College, New York, NY, USA; Sandra and Edward Meyer Cancer Center, New York, NY, USA; Caryl and Israel Englander Institute for Precision Medicine, New York, NY, USA. Electronic address: deadoc80@gmail.com.

PMID: 36543690
DOI: 10.1016/j.trecan.2022.12.005

Abstract

When used according to specific dose/fractionation schedules, focal radiotherapy can elicit a systemic anticancer immune response that limits the growth of distant, non-irradiated tumors. Recent data suggest that, at least in some settings, intratumoral macrophages can be educated by CD47 blockage to promote such an 'abscopal' response independent of CD8⁺ T cells.

Keywords: CALR; CGAS; immunogenic cell death; mitochondrial DNA; phagocytosis; type I interferon.

Publication types

Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

CD8-Positive T-Lymphocytes*
Dose Fractionation, Radiation
Humans
Neoplasms* / pathology

Grants and funding

U54 CA274291/CA/NCI NIH HHS/United States