Objective : Faced with the uncertainty about the acceptability of COVID-19 vaccination, we conducted this study to better guide communication strategies for health worker adherence to vaccination.Methods : We conducted a cross-sectional study for analytical purposes, from 15 to 26 February 2021 among health workers in health facilities in the Gbêkê health region.Results : Health workers were predominantly female (53.5 %) and the 30-39 age group was the most represented (52 %). Television was the main source of information (74.4 %). The respondents knew that they were at risk of contracting COVID-19 (82.5 %) and that people with co-morbidities were the most victim of severe forms (70.4 %). The majority of respondents systematically wear a mask in hospital (91%). They said that 51.1 % of them would get vaccinated. The majority of respondents would systematically wear a mask in hospital (91 %). Multivariate analysis shows that vaccine acceptability was statistically associated with fear of dying from the disease (p=0.046) and case management (p=0.026).Conclusion : In order to achieve better adherence to COVID-19 vaccination, it would be necessary to strengthen the capacity of these agents.