Hepatitis E Virus Infection in Pediatric Oncology

J Pediatr Hematol Oncol. 2023 Jan 1;45(1):e150-e153. doi: 10.1097/MPH.0000000000002539. Epub 2022 Dec 13.

Abstract

Background: In the 2016 ESPGHAN recommendations on how to deal with hepatitis E virus infection in immunocompromised children, patients treated with chemotherapy were not specifically mentioned.

Observations: Two teenagers treated with chemotherapy for acute leukemia and medulloblastoma, respectively, were diagnosed with hepatic cytolysis. After numerous investigations hepatitis E was found, limiting the good progress of the chemotherapy treatment.

Conclusion: In the case of liver cytolysis in immunocompromised children treated with chemotherapy, hepatitis E virus infection has to be promptly diagnosed.

MeSH terms

  • Adolescent
  • Child
  • Hepatitis E virus* / genetics
  • Hepatitis E* / diagnosis
  • Hepatitis E* / drug therapy
  • Humans
  • Immunocompromised Host
  • Leukemia*