Mosquito bypassers: infectious sporozoites grown in vitro

Laurent Rénia; Yun Shan Goh

doi:10.1016/j.pt.2022.12.011

Mosquito bypassers: infectious sporozoites grown in vitro

Trends Parasitol. 2023 Mar;39(3):158-159. doi: 10.1016/j.pt.2022.12.011. Epub 2023 Jan 4.

Authors

Laurent Rénia¹, Yun Shan Goh²

Affiliations

¹ Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore; School of Biological Sciences, Nanyang Technological University, Singapore; A*STAR Infectious Diseases Labs (A*STAR ID Labs), Agency for Science, Technology and Research (A*STAR), Singapore. Electronic address: lcsrenia@ntu.edu.sg.
² A*STAR Infectious Diseases Labs (A*STAR ID Labs), Agency for Science, Technology and Research (A*STAR), Singapore.

PMID: 36604204
DOI: 10.1016/j.pt.2022.12.011

Abstract

The whole-sporozoite-based vaccine approach has been limited by the difficulty of mass production of infectious sporozoites from infected mosquitoes. Eappen et al. describe a method for producing a large quantity of sporozoites in vitro, which opens new areas of investigations in sporozoite biology and large-scale sporozoite production for vaccine development.

Keywords: Plasmodium; in vitro; malaria; vaccines.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Anopheles*
Communicable Diseases*
Malaria Vaccines*
Malaria*
Sporozoites

Substances

Malaria Vaccines