Cyclin-D1 positive B cell lymphoma with intravascular and interstitial involvement of kidney and bone marrow

Mustafa Altinkaynak; Yagmur Goksoy; Mehmet Gokhan Gonenli; Gulcin Yegen; Sebile Nilgun Erten; Bulent Saka; Timur Selcuk Akpinar

doi:10.1007/s12185-023-03534-w

Cyclin-D1 positive B cell lymphoma with intravascular and interstitial involvement of kidney and bone marrow

Int J Hematol. 2023 Jun;117(6):925-928. doi: 10.1007/s12185-023-03534-w. Epub 2023 Jan 10.

Authors

Mustafa Altinkaynak¹, Yagmur Goksoy², Mehmet Gokhan Gonenli³, Gulcin Yegen⁴, Sebile Nilgun Erten², Bulent Saka², Timur Selcuk Akpinar²

Affiliations

¹ Department of Internal Medicine, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey. dr_mustafa86@hotmail.com.
² Department of Internal Medicine, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey.
³ Department of Internal Medicine, Koç University Hospital, Istanbul, Turkey.
⁴ Department of Pathology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey.

PMID: 36626027
DOI: 10.1007/s12185-023-03534-w

Abstract

Kidney involvement is rare in non-Hodgkin's lymphomas (NHL), and can be caused by direct lymphoid infiltration, paraneoplastic glomerulonephritis (GN), or both. Herein, we present a case of acute kidney injury (AKI) due to renal cyclin-D1 positive B cell lymphoma infiltration. To our knowledge, this is the first case where a renal biopsy revealed intravascular neoplastic cells along with parenchymal infiltration.

Keywords: B-cell lymphoma; Cyclin-D1; Kidney involvement; Leucocytoclastic vasculitis.

Publication types

Case Reports

MeSH terms

Bone Marrow / pathology
Cyclins
Humans
Kidney / pathology
Lymphoma, B-Cell* / pathology
Lymphoma, Non-Hodgkin* / pathology

Substances

Cyclins