Interactions between microbiome and underlying mechanisms in asthma

Purevsuren Losol; Milena Sokolowska; Yoon-Seok Chang

doi:10.1016/j.rmed.2023.107118

Interactions between microbiome and underlying mechanisms in asthma

Respir Med. 2023 Mar:208:107118. doi: 10.1016/j.rmed.2023.107118. Epub 2023 Jan 11.

Authors

Purevsuren Losol¹, Milena Sokolowska², Yoon-Seok Chang³

Affiliations

¹ Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, South Korea; Department of Internal Medicine, Seoul National University College of Medicine, Seoul, South Korea; Medical Research Center, Seoul National University, Seoul, South Korea; Department of Molecular Biology and Genetics, School of Biomedicine, Mongolian National University of Medical Sciences, Ulaanbaatar, Mongolia.
² Swiss Institute of Allergy and Asthma Research (SIAF), Herman-Burchard Strasse 9, CH7265, Davos, Switzerland; Christine Kühne - Center for Allergy Research and Education, Davos, Switzerland.
³ Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, South Korea; Department of Internal Medicine, Seoul National University College of Medicine, Seoul, South Korea; Medical Research Center, Seoul National University, Seoul, South Korea. Electronic address: addchang@snu.ac.kr.

PMID: 36641058
DOI: 10.1016/j.rmed.2023.107118

Abstract

Microbiome primes host innate immunity in utero and play fundamental roles in the development, training, and function of the immune system throughout the life. Interplay between the microbiome and immune system maintains mucosal homeostasis, while alterations of microbial community dysregulate immune responses, leading to distinct phenotypic features of immune-mediated diseases including asthma. Microbial imbalance within the mucosal environments, including upper and lower airways, skin, and gut, has consistently been observed in asthma patients and linked to increased asthma exacerbations and severity. Microbiome research has increased to uncover hidden microbial members, function, and immunoregulatory effects of bacterial metabolites within the mucosa. This review provides an overview of environmental and genetic factors that modulate the composition and function of the microbiome, and the impacts of microbiome metabolites and skin microbiota on immune regulation in asthma.

Keywords: Asthma; Diet; Immunity; Metabolite; Microbiome.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Asthma*
Humans
Immune System
Immunity, Innate
Microbiota*
Respiratory System