As one of the most diverse microbial communities within the human body, the oral microbiome is an important component that contributes to the maintenance of human health. The microbial composition of different sites in the oral cavity varies significantly and a dynamic equilibrium is maintained through communications with the environment and oral and distal organs of the host. It has been reported that there is significant correlation between dysbiotic oral microbiome and the occurrence or progression of a variety of systemic diseases. In this review, we summarized recent advances in research on the relationship between oral microbiome and systemic health, focusing on the interaction and pathological mechanisms between oral microbiome and systemic health and hoping to provide new avenues for the early prevention and clinical diagnosis and treatment of systemic diseases.
口腔微生物组作为人体种类最为丰富的微生物群体之一，是维持人体健康的重要组成部分。口腔的不同部位具有差异明显的微生物组成，通过与外部环境、口腔局部以及远端器官的交流实现动态平衡。研究表明，口腔微生物稳态失衡与全身多种系统性疾病的发生或进展显著相关。本文基于口腔微生物与全身系统性疾病关系的研究进展，针对口腔微生物与全身健康之间的相互作用、病理机制进行综述，为全身系统性疾病的早期预防及临床诊疗提供新的思路。
Keywords: Dysbiosis; Oral microbiome; Systemic diseases.
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